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Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 347-371 doi: 10.1007/s11684-020-0821-6

Abstract: Most of these profiles are associated with recurrent non-overlapping rearrangements or hotspot point mutationsexpression, PAX5alt (diverse alterations, including rearrangements, intragenic amplifications, or mutations), and hotspot mutations PAX5 (p.Pro80Arg) with biallelic alterations, IKZF1 (p.Asn159Tyr), and ZEB2

Keywords： BCP-ALL     subtypes     translocation     aneuploidy     sequence mutations    

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Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Frontiers of Medicine   Pages 1006-1009 doi: 10.1007/s11684-023-1000-3

Abstract: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Keywords： family craniofacial microsomia     Identification novel mutations    

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expandingTherefore, this review aimed to classify the management of NSCLC with driver mutations based on the geneThirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutictreatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutationsThis review will guide clinicians to design tailored treatments for NSCLC with driver mutations.

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 51-59 doi: 10.1007/s11684-019-0720-x

Abstract: with mutations and the relation between mutations and tuberculosis (TB) transmission.Twenty-nine nonsynonymous single mutations and three double mutations were identified.The mutations at locus 483 (11.3%) were predominant, and the mutations at V483G, W484G, I491V, L516PFifteen new mutations in the gene were identified.Rifampin resistance and mutations at locus 531 were significantly associated with mutations.

Keywords： tuberculosis     drug resistance     compensatory mutations     transmission    

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122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutationsHBV mutations were determined by direct sequencing.Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (HBV) mutations    

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Ant colony optimization for assembly sequence planning based on parameters optimization

Zunpu HAN, Yong WANG, De TIAN

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 2,   Pages 393-409 doi: 10.1007/s11465-020-0613-3

Abstract: As an important part of product design and manufacturing, assembly sequence planning (ASP) has a considerabletypical NP-complete problem that requires effective methods to find the optimal or near-optimal assembly sequenceThe assembly constraints and rules guarantee to obtain a reasonable assembly sequence.SOS) and ant colony optimization (ACO) is proposed to calculate the optimal or near-optimal assembly sequenceSOS-ACO is also robust in identifying the best assembly sequence in nearly every experiment.

Keywords： assembly sequence planning     ant colony optimization     symbiotic organisms search     parameter optimization    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemiaHowever, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlybased on 1741 patients with AML, we report a unique expression pattern associated with RUNX1 mutationswere mainly distributed in the Runt domain and almost mutually exclusive with NPM1 mutations.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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The research of grey clustering decision of assembly sequence based on petri net

Mo Qian,Luo Yi

Strategic Study of CAE 2008, Volume 10, Issue 11,   Pages 65-68

Abstract: according to the intuitionistic graphics mode characteristics of petri net, and gets feasible assembly sequenceMost of factors influencing assembly sequence are certainly qualitative, fuzzy, non-numerical, assemblysequence is regarded as a gray system, and grey clustering decision method is adopted to evaluate feasibleassembly sequence.

Keywords： assembly sequence     petri net     grey clustering decision method    

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Analysis of dispatching rules in a stochastic dynamic job shop manufacturing system with sequence-dependent

Pankaj SHARMA,Ajai JAIN

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 4,   Pages 380-389 doi: 10.1007/s11465-014-0315-9

Abstract:

Stochastic dynamic job shop scheduling problem with consideration of sequence-dependent setup times

Keywords： scheduling     stochastic dynamic job shop     sequence-dependent setup times     dispatching rule     simulation    

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunity for microbial genome. Consequently, considerable genetic diversity encoded by bacterial genomes and among the strains in the same species has been revealed. In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resulted in transformation and expedited the application of strategy and methodology for bacterial genome comparison used in dissection of infectious disease epidemics. Bacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirements of epidemiological study in disease control. In this review, we outline the significance and summarize the roles of bacterial genome sequencing in the context of bacterial disease control and prevention. We discuss the applications of bacterial genome sequencing in outbreak detection, source tracing, transmission mode discovery, and new epidemic clone identification. Wide applications of genome sequencing and data sharing in infectious disease surveillance networks will considerably promote outbreak detection and early warning to prevent the dissemination of bacterial diseases.

Keywords： genome sequencing     genomic epidemiology     bacteria     surveillance     infectious diseases    

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A novel sequence batch membrane carbonation photobioreactor developed for microalgae cultivation

Caiyun Hou, Sen Qiao, Yue Yang, Jiti Zhou

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 6, doi: 10.1007/s11783-019-1176-6

Abstract: In this study, a novel sequence batch membrane carbonation photobioreactor was developed for microalgae

Keywords： Membrane carbonation     SBM-C-PBR     Cultivate microalgae     Membrane fouling    

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Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection Review

Jiachao Zhang,Rob Knight,

Engineering 2023, Volume 20, Issue 1,   Pages 96-102 doi: 10.1016/j.eng.2021.11.018

Abstract: More human microbiome research projects—particularly those that explore genomic mutations withinWe also explore the correlation between microbial genomic mutations and common metabolic diseases, andFinally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations

Keywords： Gut microbiota     Genomic mutations     Adaptive evolution     Purifying selection     Single-nucleotide variants    

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Assembly design system based on engineering connection

Wensheng YIN

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 4,   Pages 423-432 doi: 10.1007/s11465-016-0382-1

Abstract: this model can significantly reduce the number of combinations, and is very favorable for the assembly sequence

Keywords： product design     assembly design     engineering connection     assembly sequence planning    

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Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 419-429 doi: 10.1007/s11684-010-0160-0

Abstract: The association of viral mutations and haplotypic carriages with mutations in the preS region of hepatitis, and G3191C were significantly associated with increased risks of HCC in genotype C, whereas these mutationsConclusively, the association of HBV mutations in the preS region with HCC depends on HBV genotype andhaplotypic carriage with two or more mutations that are each associated with an increased risk of HCC

Keywords： hepatitis B virus     hepatocellular carcinoma     mutation     genotype     haplotype    

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Characterization of the dissolved organic matter in sewage effluent of sequence batch reactor: the impact

Jin GUO, Feng SHENG, Jianhua GUO, Xiong YANG, Mintao MA, Yongzhen PENG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 2,   Pages 280-287 doi: 10.1007/s11783-011-0336-0

Abstract: Dissolved organic matter (DOM) transformation in sequence batch reactor (SBR) fed with carbon sources

Keywords： effluent organic matter (EfOM)     extracellular polymeric substance (EPS)     molecular weight distribution (MWD)     hydrophobic     hydrophilic     excitation emission matrices (EEM)    

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Title Author Date Type Operation

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Journal Article

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Journal Article

122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Ant colony optimization for assembly sequence planning based on parameters optimization

Zunpu HAN, Yong WANG, De TIAN

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

The research of grey clustering decision of assembly sequence based on petri net

Mo Qian,Luo Yi

Journal Article

Analysis of dispatching rules in a stochastic dynamic job shop manufacturing system with sequence-dependent

Pankaj SHARMA,Ajai JAIN

Journal Article

Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Journal Article

A novel sequence batch membrane carbonation photobioreactor developed for microalgae cultivation

Caiyun Hou, Sen Qiao, Yue Yang, Jiti Zhou

Journal Article

Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection

Jiachao Zhang,Rob Knight,

Journal Article

Assembly design system based on engineering connection

Wensheng YIN

Journal Article

Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Journal Article

Characterization of the dissolved organic matter in sewage effluent of sequence batch reactor: the impact

Jin GUO, Feng SHENG, Jianhua GUO, Xiong YANG, Mintao MA, Yongzhen PENG

Journal Article